Oestrogen receptor alpha PvuII polymorphism and uterine fibroid incidence in Caucasian women.

ABSTRACT:

Introduction

Uterine fibroids (UFs) are benign, monoclonal tumours of the female genital tract that originate from the myometrium. They may be diagnosed in as many as 80% of women depending on the selected population. UFs depend mostly on steroid hormones. Elevated levels of oestrogens and progesterone are believed to be among the most important factors inducing their formation and growth. These facts suggest that oestrogen (ESR) and progesterone receptors are crucial in UF pathophysiology as well. Previous studies have shown that, in some populations, polymorphisms in ESR genes (e.g. PvuII) constitute an important risk factor for UFs.

Material and methods

The aim of our study was to investigate whether ESRα PvuII polymorphism is associated with an increased risk of UFs in C

SUBMITTER: Ciebiera M 

PROVIDER: S-EPMC6372853 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature