Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort.

ABSTRACT:

Objective

To determine whether infection with human enterovirus or adenovirus, both common intestinal viruses, predicts development of coeliac disease.

Design

Case-control study nested within Norwegian birth cohort recruited between 2001 and 2007 and followed to September 2016.

Setting

Norwegian population.

Participants

Children carrying the HLA genotype DR4-DQ8/DR3-DQ2 conferring increased risk of coeliac disease.

Exposures

Enterovirus and adenovirus detected using real time polymerase chain reaction in monthly stool samples from age 3 to 36 months.

Main outcome measure

Coeliac disease diagnosed according to standard criteria. Coeliac disease antibodies were tested in blood samples taken at age 3, 6, 9, and 12 months and then annually. Adjusted o

SUBMITTER: Kahrs CR 

PROVIDER: S-EPMC6372922 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature