The role of the vasculature niche on insulin-producing cells generated by transdifferentiation of adult human liver cells.

ABSTRACT:

Background

Insulin-dependent diabetes is a multifactorial disorder that could be theoretically cured by functional pancreatic islets and insulin-producing cell (IPC) implantation. Regenerative medicine approaches include the potential for growing tissues and organs in the laboratory and transplanting them when the body cannot heal itself. However, several obstacles remain to be overcome in order to bring regenerative medicine approach for diabetes closer to its clinical implementation; the cells generated in vitro are typically of heterogenic and immature nature and the site of implantation should be readily vascularized for the implanted cells to survive in vivo. The present study addresses these two limitations by analyzing the effect of co-implanting IPCs with vasculature promot

SUBMITTER: Meivar-Levy I 

PROVIDER: S-EPMC6373031 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature