Glucocorticoid-induced enhancement of extinction-from animal models to clinical trials.

ABSTRACT: Extensive evidence from both animal model and human research indicates that glucocorticoid hormones are crucially involved in modulating memory performance. Glucocorticoids, which are released during stressful or emotionally arousing experiences, enhance the consolidation of new memories, including extinction memory, but reduce the retrieval of previously stored memories. These memory-modulating properties of glucocorticoids have recently received considerable interest for translational purposes because strong aversive memories lie at the core of several fear-related disorders, including post-traumatic stress disorder and phobias. Moreover, exposure-based psychological treatment of these disorders relies on successful fear extinction. In this review, we argue that glucocorticoid-based inte

SUBMITTER: de Quervain D 

PROVIDER: S-EPMC6373196 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature