Suhuai suckling piglet hindgut microbiome-metabolome responses to different dietary copper levels.

ABSTRACT: Unabsorbed copper accumulates in the hindgut of pigs that consume high levels of dietary copper, which enhances the coselection of antibiotic-resistant bacteria and is considered detrimental to the environment and to porcine health. In our study, a combination of 16S rRNA pyrosequencing and nontargeted metabolomics was used to investigate the microbiome-metabolome responses to dietary copper levels in the hindgut of suckling piglets. The results showed that the dietary copper level affected the abundance of several Clostridia genera and that the relative abundance of butyrate-producing bacteria, such as Coprococcus, Roseburia, and Acidaminococcus, was reduced in the 300 mg kg^-1 (high) Cu group. Metabolomic analysis revealed that dietary copper levels affected protein and carbohy

SUBMITTER: Zhang F 

PROVIDER: S-EPMC6373200 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature