Relation of the degree of obesity in childhood to adipose tissue insulin resistance.

ABSTRACT:

Aims

In this study, we investigated whether adipose tissue insulin resistance (IR) is affected by the degree of obesity during the fasting and post-prandial state, independent of glucose tolerance among obese children and adolescents. We also tested whether systemic subclinical inflammation is associated with adipose tissue IR.

Methods

Subjects were recruited to the Yale Pathophysiology of Type 2 Diabetes in Youth Study (NCT01967849). An oral glucose-tolerance test was performed to establish glucose-tolerance status and blood samples were drawn for measurement of free fatty acids (FFAs), to calculate the area under the curve (AUC) of FFA. Adipose tissue insulin resistance was calculated as the product of insulin and FFA concentrations.

Results

In total, 671 children a

SUBMITTER: Hagman E 

PROVIDER: S-EPMC6373259 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature