Deficiency of the clock gene Bmal1 affects neural progenitor cell migration.

ABSTRACT: We demonstrate the impact of a disrupted molecular clock in Bmal1-deficient (Bmal1^-/-) mice on migration of neural progenitor cells (NPCs). Proliferation of NPCs in rostral migratory stream (RMS) was reduced in Bmal1^-/- mice, consistent with our earlier studies on adult neurogenesis in hippocampus. However, a significantly higher number of NPCs from Bmal1^-/- mice reached the olfactory bulb as compared to wild-type littermates (Bmal1^+/+ mice), indicating a higher migration velocity in Bmal1^-/- mice. In isolated NPCs from Bmal1^-/- mice, not only migration velocity and expression pattern of genes involved in detoxification of reactive oxygen species were affected, but also RNA oxidation of catalase was increased and catalase pr

SUBMITTER: Ali AAH 

PROVIDER: S-EPMC6373387 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature