The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach.

ABSTRACT: Like virtually all age-related chronic diseases, late-onset Alzheimer's disease (AD) develops over an extended preclinical period and is associated with modifiable lifestyle and environmental factors. We hypothesize that multimodal interventions that address many risk factors simultaneously and are individually tailored to patients may help reduce AD risk. We describe a novel clinical methodology used to evaluate and treat patients at two Alzheimer's Prevention Clinics. The framework applies evidence-based principles of clinical precision medicine to tailor individualized recommendations, follow patients longitudinally to continually refine the interventions, and evaluate N-of-1 effectiveness (trial registered at ClinicalTrials.gov NCT03687710). Prior preliminary results suggest that the c

SUBMITTER: Isaacson RS 

PROVIDER: S-EPMC6373477 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature