Mortality and Exacerbations by Global Initiative for Chronic Obstructive Lung Disease Groups ABCD: 2011 Versus 2017 in the COPDGene® Cohort.

ABSTRACT: Background: The Global initiative for chronic Obstructive Lung Disease (GOLD) ABCD groupings were recently modified. The GOLD 2011 guidelines defined increased risk as forced expiratory volume in 1 second (FEV₁) < 50% predicted or ≥ 2 outpatient or ≥ 1 hospitalized exacerbation in the prior year, whereas the GOLD 2017 guidelines use only exacerbation history. We compared mortality and exacerbation rates in the Genetic Epidemiology of COPD Study cohort (COPDGene^®) by 2011 (exacerbation history/FEV₁ and dyspnea) versus 2017 (exacerbations and dyspnea) classifications. Methods: Using data from COPDGene^®, we tested associations of ABCD groups with all-cause mortality (Cox models, adjusted for age, sex, race and comorbidities) and longit

SUBMITTER: Criner RN 

PROVIDER: S-EPMC6373581 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature