Relative neuron loss in hippocampal sclerosis of aging and Alzheimer's disease.

ABSTRACT:

Objective

To characterize the pattern of neuron loss in hippocampal sclerosis of aging (HS-Aging) and age-related diseases and to evaluate its contribution to cognitive impairment in the elderly.

Methods

Participants (n = 1,361) came from longitudinal observational studies of aging at the Knight Alzheimer Disease Research Center, Washington University (St. Louis, MO). Relative neuron loss in the hippocampus of HS-Aging was measured using unbiased stereological methods. Transactive response DNA-binding protein of 43 kDa (TDP-43) proteinopathy, a putative marker of HS-Aging, was assessed. Clinical and cognitive data were analyzed using parametric statistical methods.

Results

Ninety-three cases had HS-Aging (6.8%), 8 cases had "pure" HS-Aging, and 37 cases had comorbid i

SUBMITTER: Ihara R 

PROVIDER: S-EPMC6373729 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature