Ovine uterine space restriction causes dysregulation of the renin-angiotensin system in fetal kidneys.

ABSTRACT: In ovine pregnancy, uterine space restriction (USR) resulting from decreased space for placental attachment caused intrauterine growth restriction and impaired nephrogenesis. The fetal kidney renin-angiotensin system (RAS) is involved in nephrogenesis, fluid balance, and iron deposition. Angiotensin II exerts its effects via multiple receptors: angiotensin II 1-8 receptor type 1 (AT 1 R) and type 2 (AT 2 R), and angiotensin II 1-7 Mas receptor (MASR).

Objective

: To test the hypothesis that ovine USR is associated with dysregulation of the fetal renal RAS.

Methods

: Multiparous pregnant ewes (n = 32), 16 with surgical bifurcated disconnection of one uterine horn to further reduce placental attachment sites, were studied. USR (n = 31) ovine fetuses were compared to nonspace re

SUBMITTER: Kranch-Shorthouse RA 

PROVIDER: S-EPMC6373835 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature