Cardiopulmonary responses to maximal aerobic exercise in patients with cystic fibrosis.

ABSTRACT: Cystic fibrosis (CF) is a debilitating chronic condition, which requires complex and expensive disease management. Exercise has now been recognised as a critical factor in improving health and quality of life in patients with CF. Hence, cardiopulmonary exercise testing (CPET) is used to determine aerobic fitness of young patients as part of the clinical management of CF. However, at present there is a lack of conclusive evidence for one limiting system of aerobic fitness for CF patients at individual patient level. Here, we perform detailed data analysis that allows us to identify important systems-level factors that affect aerobic fitness. We use patients' data and principal component analysis to confirm the dependence of CPET performance on variables associated with ventilation and metab

SUBMITTER: Williams CA 

PROVIDER: S-EPMC6373911 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature