Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals.

ABSTRACT:

Objectives

Reversing HIV-1 latency has been suggested as a strategy to eradicate HIV-1. We investigated the effect of romidepsin on the HIV transcription profile in participants from the REDUC part B clinical trial.

Design

Seventeen participants on suppressive antiretroviral therapy were vaccinated with six doses of the therapeutic vaccine Vacc-4x followed by treatment with three doses of romidepsin. Samples from nine study participants were available for HIV transcription profile analysis.

Methods

Read-through, total (TAR), elongated (longLTR), polyadenylated (polyA) and multiply-spliced (Tat-Rev) HIV transcripts and total HIV DNA were quantified at baseline (visit 1) and 4 h after the second (visit 10b) and third (visit 11b) romidepsin infusions.

Results

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SUBMITTER: Moron-Lopez S 

PROVIDER: S-EPMC6374101 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature