Phosphoproteomic analysis of cocaine memory extinction and reconsolidation in the nucleus accumbens.

ABSTRACT:

Rationale

Environmental stimuli, or cues, associated with the use of drugs such as cocaine are one of the primary drivers of relapse. Thus, identifying mechanisms to reduce the motivational properties of drug cues is an important research goal.

Objectives

The purpose of this study was to identify cellular signaling events in the nucleus accumbens (NAc) that are induced when a cocaine cue memory is either extinguished through repeated cue presentation in the absence of drug, or when the memory is reactivated and reconsolidated by a brief cue re-exposure. Signaling events specific to extinction or reconsolidation represent potential targets for pharmacotherapeutics that may enhance extinction or disrupt reconsolidation to reduce the likelihood of relapse.

Methods

Male S

SUBMITTER: Torregrossa MM 

PROVIDER: S-EPMC6374162 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature