Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries.

ABSTRACT:

Aims/hypothesis

We aimed to determine the association of maternal metabolites with newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother-newborn dyads.

Methods

Targeted and non-targeted metabolomics assays were performed on fasting and 1 h serum samples from a total of 1600 mothers in four ancestry groups (Northern European, Afro-Caribbean, Mexican American and Thai) who participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study, underwent an OGTT at ~28 weeks gestation and whose newborns had anthropometric measurements at birth.

Results

In this observational study, meta-analyses demonstrated significant associations of maternal fasting and 1 h metabolites with birthweight, cord C-peptide and/or sum of skinfolds across ancestry g

SUBMITTER: Kadakia R 

PROVIDER: S-EPMC6374187 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature