Loss of X-box binding protein 1 in Muller cells augments retinal inflammation in a mouse model of diabetes.

ABSTRACT:

Aims/hypothesis

Müller glia (MG) are major sources of retinal cytokines, and their activation is closely linked to retinal inflammation and vascular leakage in diabetic retinopathy. Previously, we demonstrated that X-box binding protein 1 (XBP1), a transcription factor activated by endoplasmic reticulum (ER) stress in diabetic retinopathy, is involved in regulation of inflammation in retinal endothelial cells. Now, we have explored the role of XBP1 and ER stress in the regulation of MG-derived proinflammatory factors, and their influence on vascular permeability in diabetic retinopathy.

Methods

MG-specific conditional Xbp1 knockout (Xbp1^Müller-/-) mice were generated by crossing Xbp1 flox/flox mice with Müller-Cre transgenic mice. Diabetes was modelled by inductio

SUBMITTER: Yang J 

PROVIDER: S-EPMC6374194 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature