A Systematic Review and Meta-analysis of the Association Between Vitamin K Antagonist Use and Fracture.

ABSTRACT:

Background

Vitamin K antagonist (VKA) anticoagulant use is suspected to increase the risk of bone fracture through inhibition of vitamin K-dependent cofactors of bone formation, an effect not seen with non-vitamin K antagonist oral anticoagulants (NOACs). The purpose of our systematic review and meta-analysis is to investigate the association between VKA use and fracture.

Methods

We searched PubMed, EMBASE, and Cochrane Library for studies analyzing fracture in adults using VKAs versus controls. Two authors independently reviewed articles. We assessed for risk of bias using the Newcastle-Ottawa Quality Assessment Scale and the Cochrane Risk of Bias Tool and calculated pooled effects using random effects models.

Results

We included 23 articles (22 observational studies

SUBMITTER: Fiordellisi W 

PROVIDER: S-EPMC6374254 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature