Ambient and controlled exposures to particulate air pollution and acute changes in heart rate variability and repolarization.

ABSTRACT: Previous studies have reported increased risks of myocardial infarction in association with elevated ambient particulate matter (PM) in the previous hour(s). However, whether PM can trigger mechanisms that act on this time scale is still unclear. We hypothesized that increases in PM are associated with rapid changes in measures of heart rate variability and repolarization. We used data from panel studies in Augsburg, Germany, and Rochester, New York, USA, and two controlled human exposure studies in Rochester. Data included ECG recordings from all four studies, controlled exposures to (concentrated) ultrafine particles (UFP; particles with an aerodynamic diameter <100 nm) and ambient concentrations of UFP and fine PM (PM_2.5, aerodynamic diameter <2.5 μm). Factor analysis identif

SUBMITTER: Breitner S 

PROVIDER: S-EPMC6374365 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature