L-PGDS-produced PGD₂ in premature, but not in mature, adipocytes increases obesity and insulin resistance.

ABSTRACT: Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD₂ in adipocytes and is selectively induced by a high-fat diet (HFD) in adipose tissue. In this study, we investigated the effects of HFD on obesity and insulin resistance in two distinct types of adipose-specific L-PGDS gene knockout (KO) mice: fatty acid binding protein 4 (fabp4, aP2)-Cre/L-PGDS ^flox/flox and adiponectin (AdipoQ)-Cre/L-PGDS ^flox/flox mice. The L-PGDS gene was deleted in adipocytes in the premature stage of the former strain and after maturation of the latter strain. The L-PGDS expression and PGD₂ production levels decreased in white adipose tissue (WAT) under HFD conditions only in the aP2-Cre/L-PGDS ^flox/flox mice, but were

SUBMITTER: Fujimori K 

PROVIDER: S-EPMC6374461 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature