MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1.

ABSTRACT: Endometriosis is associated with benign but adversely developed cysts in the extrauterine environment. The oxidative imbalanced environment induces DNA damage and affects cell cycle progression of endometrial stromal cells (ESCs) and endometrial epithelial cells, but how endometriotic cells maintain proliferation in the presence of oxidative stress is not clear. Growing evidence has indicated that the ectopic hypoxic microenvironment and oxidative stress can stimulate the growth of endometriotic cells, which is mainly due to the increase of HIF-1α. We found that the master hypoxia-associated miRNA miR-210-3p was increased in stromal and glandular cells of ectopic lesions compared with that of eutopic and normal endometria and was consistent with the expression of HIF-1α and the local oxida

SUBMITTER: Dai Y 

PROVIDER: S-EPMC6374490 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature