Transcriptome Sequencing Investigated the Tumor-Related Factors Changes After T. gondii Infection.

ABSTRACT: Toxoplasma gondii is an intracellular parasite and causes a global epidemic parasitic disease. T. gondii-infection could inhibit the growth of tumor. In this study, the transcriptomes of samples were detected by deep sequencing analysis. The transcriptome data was compared with reference genome to perform sequence alignment and the further analysis. The analyses of differential expression and the differentially expressed genes were performed in the present study. Genes involved in P53 signaling pathway, COLORECTAL cancer pathway, NON-SMALL CELL LUNG cancer signaling pathway, and BREAST cancer signaling pathway were up-regulated or down-regulated among the samples. The KEGG analysis indicated that the cancer pathways changed after infection of T. gondii. Furtherm

SUBMITTER: Lu G 

PROVIDER: S-EPMC6374557 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature