A Controlled Human Infection Model of Group A <i>Streptococcus</i> Pharyngitis: Which Strain and Why?

ABSTRACT: Group A Streptococcus (GAS) is a major cause of global infection-related morbidity and mortality. A modern controlled human infection model (CHIM) of GAS pharyngitis can accelerate vaccine development and pathogenesis research. A robust rationale for strain selection is central to meeting ethical, scientific, and regulatory requirements. Multifaceted characterization studies were done to compare a preferred candidate emm75 (M75) GAS strain to three other strains: an alternative candidate emm12 (M12) strain, an M1 strain used in 1970s pharyngitis CHIM studies (SS-496), and a representative (5448) of the globally disseminated M1T1 clone. A range of approaches were used to explore strain growth, adherence, invasion, delivery characteristics, short- and long-term viability

SUBMITTER: Osowicki J 

PROVIDER: S-EPMC6374595 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature