Metastable neural dynamics in Alzheimer's disease are disrupted by lesions to the structural connectome.

ABSTRACT: Current theory suggests brain regions interact to reconcile the competing demands of integration and segregation by leveraging metastable dynamics. An emerging consensus recognises the importance of metastability in healthy neural dynamics where the transition between network states over time is dependent upon the structural connectivity between brain regions. In Alzheimer's disease (AD) - the most common form of dementia - these couplings are progressively weakened, metastability of neural dynamics are reduced and cognitive ability is impaired. Accordingly, we use a joint empirical and computational approach to reveal how behaviourally relevant changes in neural metastability are contingent on the structural integrity of the anatomical connectome. We estimate the metastability of fMRI BOL

SUBMITTER: Alderson TH 

PROVIDER: S-EPMC6374703 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature