Immediate-term cognitive impairment following intravenous (IV) chemotherapy: a prospective pre-post design study.

ABSTRACT:

Background

Cognitive impairment is commonly reported in patients receiving chemotherapy, but the acuity of onset is not known. This study utilized the psychomotor vigilance test (PVT) and trail-making test B (TMT-B) to assess cognitive impairment immediately post-chemotherapy.

Methods

Patients aged 18-80 years receiving first-line intravenous chemotherapy for any stage of breast or colorectal cancer were eligible. Patient symptoms, peripheral neuropathy and Stanford Sleepiness Scale were assessed. A five-minute PVT and TMT-B were completed on a tablet computer pre-chemotherapy and immediately post-chemotherapy. Using a mixed linear regression model, changes in reciprocal transformed PVT reaction time (mean 1/RT) were assessed. A priori, an increase in median PVT reaction tim

SUBMITTER: Khan OF 

PROVIDER: S-EPMC6375158 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature