Epigenetic findings in periodontitis in UK twins: a cross-sectional study.

ABSTRACT:

Background

Genetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms are malleable regulators of gene function that can change in response to genetic and environmental stimuli, thereby providing a potential mechanism for mediating risk effects in periodontitis. The aim of this study is to identify epigenetic changes across tissues that are associated with periodontal disease.

Methods

Self-reported gingival bleeding and history of gum disease, or tooth mobility, were used as indicators of periodontal disease. DNA methylation profiles were generated using the Infinium HumanMethylation450 BeadChip in whole blood, buccal, and adipose tissue samples from predominantly older

SUBMITTER: Kurushima Y 

PROVIDER: S-EPMC6375219 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature