Mangrove derived Streptomyces sp. MUM265 as a potential source of antioxidant and anticolon-cancer agents.

ABSTRACT:

Background

Colon cancer is the third most commonly diagnosed cancer worldwide, with a commensurately high mortality rate. The search for novel antioxidants and specific anticancer agents which may inhibit, delay or reverse the development of colon cancer is thus an area of great interest; Streptomyces bacteria have been demonstrated to be a source of such agents.

Results

The extract from Streptomyces sp. MUM265- a strain which was isolated and identified from Kuala Selangor mangrove forest, Selangor, Malaysia- was analyzed and found to exhibit antioxidant properties as demonstrated via metal-chelating ability as well as superoxide anion, DPPH and ABTS radical scavenging activities. This study also showed that MUM265 extract demonstrated cytotoxicity against colon cancer cell

SUBMITTER: Tan LT 

PROVIDER: S-EPMC6375222 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature