The Lag Structure of Intrinsic Activity is Focally Altered in High Functioning Adults with Autism.

ABSTRACT: The behaviors that define autism spectrum disorders (ASDs) have been hypothesized to result from disordered communication within brain networks. Several groups have investigated this question using resting-state functional magnetic resonance imaging (RS-fMRI). However, the published findings to date have been inconsistent across laboratories. Prior RS-fMRI studies of ASD have employed conventional analysis techniques based on the assumption that intrinsic brain activity is exactly synchronous over widely separated parts of the brain. By relaxing the assumption of synchronicity and focusing, instead, on lags between time series, we have recently demonstrated highly reproducible patterns of temporally lagged activity in normal human adults. We refer to this analysis technique as resting-stat

SUBMITTER: Mitra A 

PROVIDER: S-EPMC6375249 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature