Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in Helicobacter pylori.

ABSTRACT:

Background

Metronidazole is one of the first-line drugs of choice in the standard triple therapy used to eradicate Helicobacter pylori infection. Hence, the global emergence of metronidazole resistance in Hp poses a major challenge to health professionals. Inactivation of RdxA is known to be a major mechanism of conferring metronidazole resistance in H. pylori. However, metronidazole resistance can also arise in H. pylori strains expressing functional RdxA protein, suggesting that there are other mechanisms that may confer resistance to this drug.

Methods

We performed whole-genome sequencing on 121 H. pylori clinical strains, among which 73 were metronidazole-resistant. Sequence-alignment analysis of core protein clusters derived from clini

SUBMITTER: Chua EG 

PROVIDER: S-EPMC6375344 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature