Evaluating the effectiveness of infliximab on perianal fistulizing Crohn's disease by magnetic resonance imaging.

ABSTRACT:

Background and aim

Data on the radiologic evaluation of perianal fistulizing Crohn's disease (PFCD) naïve to anti-tumor necrosis factor therapy are scarce, especially in Asian populations. We assessed the effectiveness of infliximab (IFX) on PFCD and explored predictors of 'deep remission' based on clinical and radiologic assessments.

Methods

Patients with Crohn's disease and active anal fistulas attending our care center for IFX therapy were prospectively enrolled. Each patient underwent clinical examination according to the Fistula Drainage Assessment Index, endoscopy for assessment of Crohn's Disease Activity Index (CDAI) and Perianal Crohn's Disease Activity Index (PCDAI), magnetic resonance imaging (MRI) to determine Van Assche score and Ng score, and laboratory tests u

SUBMITTER: Yan X 

PROVIDER: S-EPMC6375345 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature