Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA).

ABSTRACT:

Background

Epigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health.

Objective

We sought to examine the associations of residential proximity to roadways at birth and epigenome-wide DNA methylation. We also assessed associations of differential methylation with child cognitive outcomes.

Methods

We estimated residential proximity to roadways at birth using a geographic information system (GIS) and cord blood methylation using Illumina's HumanMethylation450-array in 482 mother-child pairs in Project Viva. We identified individual CpGs associated with residential-proximity-to-roadways at birth using robust linear regression [[Formula: see text]]. We also estimated association between proxim

SUBMITTER: Peng C 

PROVIDER: S-EPMC6375460 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature