Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners.

ABSTRACT:

Purpose

Radon is a risk factor for lung cancer and uranium miners are more exposed than the general population. A genome-wide interaction analysis was carried out to identify genomic loci, genes or gene sets that modify the susceptibility to lung cancer given occupational exposure to the radioactive gas radon.

Methods

Samples from 28 studies provided by the International Lung Cancer Consortium were pooled with samples of former uranium miners collected by the German Federal Office of Radiation Protection. In total, 15,077 cases and 13,522 controls, all of European ancestries, comprising 463 uranium miners were compared. The DNA of all participants was genotyped with the OncoArray. We fitted single-marker and in multi-marker models and performed an exploratory gene-set analys

SUBMITTER: Rosenberger A 

PROVIDER: S-EPMC6375683 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature