A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome.

ABSTRACT: Molecular- and cellular-based therapies have the potential to reduce obesity-associated disease. In response to cold, beige adipocytes form in subcutaneous white adipose tissue and convert energy stored in metabolic substrates to heat, making them an attractive therapeutic target. We developed a robust method to generate a renewable source of human beige adipocytes from induced pluripotent stem cells (iPSCs). Developmentally, these cells are derived from FOXF1⁺ mesoderm and progress through an expandable mural-like mesenchymal stem cell (MSC) to form mature beige adipocytes that display a thermogenically active profile. This includes expression of uncoupling protein 1 (UCP1) concomitant with increased uncoupled respiration. With this method, dysfunctional adipogenic precursors c

SUBMITTER: Su S 

PROVIDER: S-EPMC6375695 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature