Magnetic carbon nanocomposites as a MALDI co-matrix enhancing MS-based glycomics.

ABSTRACT: More than 50% of all known proteins are glycosylated, which is critical for many biological processes such as protein folding and signal transduction. Glycosylation has proven to be associated with different mammalian diseases such as breast and liver cancers. Therefore, characterization of glycans is highly important to facilitate a better understanding of the development and progression of many human diseases. Although matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) offers several advantages such as ease of operation and short analysis times, however, due to the complexity of glycan structures and their low ionization efficiency, there are still challenges that need to be addressed to achieve sensitive glycan analysis. Here, magnetic carbon nanocomposites (CNPs@F

SUBMITTER: Banazadeh A 

PROVIDER: S-EPMC6375713 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature