Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies.

ABSTRACT: We aimed to report the first genomewide association study (GWAS) meta-analysis of dual-energy X-ray absorptiometry (DXA)-derived hip shape, which is thought to be related to the risk of both hip osteoarthritis and hip fracture. Ten hip shape modes (HSMs) were derived by statistical shape modeling using SHAPE software, from hip DXA scans in the Avon Longitudinal Study of Parents and Children (ALSPAC; adult females), TwinsUK (mixed sex), Framingham Osteoporosis Study (FOS; mixed), Osteoporotic Fractures in Men study (MrOS), and Study of Osteoporotic Fractures (SOF; females) (total N = 15,934). Associations were adjusted for age, sex, and ancestry. Five genomewide significant (p < 5 × 10^-9 , adjusted for 10 independent outcomes) single-nucleotide polymorphisms (SNPs) were associate

SUBMITTER: Baird DA 

PROVIDER: S-EPMC6375741 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature