Relationships Between Adipose Mitochondrial Function, Serum Adiponectin, and Insulin Resistance in Persons With HIV After 96 Weeks of Antiretroviral Therapy.

ABSTRACT:

Objective

Some antiretroviral therapy (ART) and HIV itself confer metabolic risk, perhaps through altered mitochondrial function and adipokines. In AIDS Clinical Trials Group study A5224s, adipose mitochondrial DNA (mtDNA) levels decreased on ART, and electron transport chain complex I (CI) and complex IV (CIV) activity decreased. Another study found decreased serum adiponectin on ART with mtDNA mutation m.10398A>G. We hypothesized that decreased adipose tissue mitochondrial function would be associated with lower adiponectin and insulin sensitivity on ART, and m.10398G would influence these changes.

Design

Retrospective analysis of an ART-naive substudy population from A5224s.

Methods

Analyses included adipose mtDNA levels, CI and CIV activity by immunoassay, viscera

SUBMITTER: Hulgan T 

PROVIDER: S-EPMC6375746 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature