Angular range, sampling and noise considerations for inverse light scattering analysis of nuclear morphology.

ABSTRACT: In recent years, significant work has been devoted to the use of angle-resolved elastic scattering for the extraction of nuclear morphology in tissue. By treating the nucleus as a Mie scattering object, techniques such as angle-resolved low-coherence interferometry (a/LCI) have demonstrated substantial success in identifying nuclear alterations associated with dysplasia. Because optical biopsies are inherently noninvasive, only a small, discretized portion of the 4π scattering field can be collected from tissue, limiting the amount of information available for diagnostic purposes. In this work, we comprehensively characterize the diagnostic impact of variations in angular sampling, range and noise for inverse light scattering analysis of nuclear morphology, using a previously reported data

SUBMITTER: Zhang H 

PROVIDER: S-EPMC6375761 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature