Disease- and Treatment-related Morbidity in Adolescents With Perinatal HIV Infection in Asia.

ABSTRACT:

Background

Perinatally HIV-infected adolescents (PHIVA) are exposed to a chronic systemic infection and long-term antiretroviral therapy (ART), leaving them susceptible to morbidities associated with inflammation, immunodeficiency and drug toxicity.

Methods

Data collected 2001 to 2016 from PHIVA 10-19 years of age within a regional Asian cohort were analyzed using competing risk time-to-event and Poisson regression analyses to describe the nature and incidence of morbidity events and hospitalizations and identify factors associated with disease-related, treatment-related and overall morbidity. Morbidity was defined according to World Health Organization clinical staging criteria and U.S. National Institutes of Health Division of AIDS criteria.

Results

A total 3,448 PH

SUBMITTER: Bartlett AW 

PROVIDER: S-EPMC6375771 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature