Estimating cross-population genetic correlations of causal effect sizes.

ABSTRACT: Recent studies have examined the genetic correlations of single-nucleotide polymorphism (SNP) effect sizes across pairs of populations to better understand the genetic architectures of complex traits. These studies have estimated ρ g , the cross-population correlation of joint-fit effect sizes at genotyped SNPs. However, the value of ρ g depends both on the cross-population correlation of true causal effect sizes ( ρ b ) and

SUBMITTER: Galinsky KJ 

PROVIDER: S-EPMC6375794 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature