Histopathological Features and Composition of Gut Microbiota in Rhesus Monkey of Alcoholic Liver Disease.

ABSTRACT: Alcohol-induced chronic liver disease (ALD) is becoming the most common liver disease in the world. However, there are no effective, universally accepted therapies for ALD. The etiology of ALD remains blurry so far. Historical evidence has demonstrated a link between the liver and gut microbiota. But it is difficult to distinguish the effect of gut microbiota changes caused by alcohol consumption in humans since the microbiota change detected in humans is complicated by diet and environmental factors. Due to the genetic, physiological, metabolic, and behavioral similarities to humans, the rhesus monkey provides excellent translational validity in preclinical studies, and the diet and environmental conditions can be controlled well in rhesus monkey. In our study, we explored the relationshi

SUBMITTER: Wang H 

PROVIDER: S-EPMC6375900 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature