Network controllability analysis of intracellular signalling reveals viruses are actively controlling molecular systems.

ABSTRACT: In recent years control theory has been applied to biological systems with the aim of identifying the minimum set of molecular interactions that can drive the network to a required state. However, in an intra-cellular network it is unclear how control can be achieved in practice. To address this limitation we use viral infection, specifically human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV), as a paradigm to model control of an infected cell. Using a large human signalling network comprised of over 6000 human proteins and more than 34000 directed interactions, we compared two states: normal/uninfected and infected. Our network controllability analysis demonstrates how a virus efficiently brings the dynamically organised host system into its control by mostly targetin

SUBMITTER: Ravindran V 

PROVIDER: S-EPMC6375943 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature