Sepsis and Risk of Cancer Among Elderly Adults in the United States.

ABSTRACT:

Background

Sepsis is an important cause of mortality among older adults in the United States. The association between sepsis and subsequent risk of cancer is poorly understood.

Methods

Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database, we conducted a case-control study in US adults. We included 1801156 cases with a first cancer diagnosis in SEER during 1992-2013 (ages 66-115 years) and 200000 cancer-free controls from a 5% random sample of Medicare beneficiaries. Sepsis was identified using inpatient Medicare claims. Associations with sepsis were estimated using logistic regression.

Results

After correction for multiple comparisons, sepsis was significantly associated with increased risk for cancers of the colon (adjusted odds ratio

SUBMITTER: Liu Z 

PROVIDER: S-EPMC6376110 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature