Nuclear nanomedicine using Si nanoparticles as safe and effective carriers of ¹⁸⁸Re radionuclide for cancer therapy.

ABSTRACT: Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, provides unique opportunities to treat tumors and metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack of suitable nanocarriers, which are safe, excretable and have favorable pharmacokinetics to efficiently deliver and retain radionuclides in a tumor. Here, we introduce biodegradable laser-synthesized Si nanoparticles having round shape, controllable low-dispersion size, and being free of any toxic impurities, as highly suitable carriers of therapeutic ¹⁸⁸Re radionuclide. The conjugation of the polyethylene glycol-coated Si nanoparticles with radio

SUBMITTER: Petriev VM 

PROVIDER: S-EPMC6376125 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature