Ontology highlight
ABSTRACT:
SUBMITTER: Sachs N
PROVIDER: S-EPMC6376275 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20190114 4
Organoids are self-organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and function. Here, we describe a method to establish long-term-expanding human airway organoids from broncho-alveolar resections or lavage material. The pseudostratified airway organoids consist of basal cells, functional multi-ciliated cells, mucus-producing secretory cells, and CC10-secreting club cells. Airway organoids derived from cystic fibrosis (CF) patients allow asse ...[more]