Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3.

ABSTRACT: Alzheimer's disease is characterized not only by extracellular amyloid plaques and neurofibrillary tangles, but also by microglia-mediated neuroinflammation. Recently, autophagy has been linked to the regulation of the inflammatory response. Thus, we investigated how an impairment of autophagy mediated by BECN1/Beclin1 reduction, as described in Alzheimer's disease patients, would influence cytokine production of microglia. Acutely stimulated microglia from Becn1^+/- mice exhibited increased expression of IL-1beta and IL-18 compared to wild-type microglia. Becn1^+/-APPPS1 mice also contained enhanced IL-1beta levels. The investigation of the IL-1beta/IL-18 processing pathway showed an elevated number of cells with inflammasomes and increased levels

SUBMITTER: Houtman J 

PROVIDER: S-EPMC6376276 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature