Novel susceptibility variants at the <i>ERG</i> locus for childhood acute lymphoblastic leukemia in Hispanics.

ABSTRACT: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Characterized by high levels of Native American ancestry, Hispanics are disproportionally affected by this cancer with high incidence and inferior survival. However, the genetic basis for this disparity remains poorly understood because of a paucity of genome-wide investigation of ALL in Hispanics. Performing a genome-wide association study (GWAS) in 940 Hispanic children with ALL and 681 ancestry-matched non-ALL controls, we identified a novel susceptibility locus in the ERG gene (rs2836365; P = 3.76 × 10^-8; odds ratio [OR] = 1.56), with independent validation (P = .01; OR = 1.43). Imputation analyses pointed to a single causal variant driving the association signal at this locus

SUBMITTER: Qian M 

PROVIDER: S-EPMC6376278 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature