Anti-metastatic Properties of Naproxen-HBTA in a Murine Model of Cutaneous Melanoma.

ABSTRACT: The beneficial effects of H₂S-release and of COXs-inhibition have been exploited in the design of novel anti-inflammatory drugs, the H₂S-releasing non-steroidal anti-inflammatory drugs (H₂S-NSAIDs), showing promising potential for chemoprevention in cancers. Here, we evaluated the efficacy of a new H₂S-releasing derivative of naproxen, named naproxen-4-hydroxybenzodithioate (naproxen-HBTA), in reducing metastatic melanoma features, both in vitro and in vivo. The novel H₂S donor has been prepared following a synthetic scheme that provided high yields and purity. In particular, we investigated the effect of naproxen-HBTA in vitro on several metastatic features of human melanoma cells such as proliferation, migration,

SUBMITTER: Ercolano G 

PROVIDER: S-EPMC6376415 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature