Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression.

ABSTRACT: Rationale: Endometriosis is a highly prevalent gynecological disease in women of reproductive age that markedly reduces life quality and fertility. Unfortunately, there is no cure for this disease, which highlights that more efforts are needed to investigate the underlying mechanism for designing novel therapeutic regimens. This study aims to investigate druggable membrane receptors distinctively expressed in endometriotic cells. Methods: Bioinformatic analysis of public databases was employed to identify potential druggable candidates. Normal endometrial tissues and ectopic endometriotic lesions were obtained for the determination of target genes. Primary endometrial and endometriotic stromal cells as well as two different mouse models of endometriosis were used to character

SUBMITTER: Lin SC 

PROVIDER: S-EPMC6376465 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature