The association between apelin polymorphisms and hypertension in China: A meta-analysis.

ABSTRACT:

Introduction:

Apelin plays an important part in regulating blood pressure, metabolism, and the development of cancer. Recent studies have investigated the association of apelin polymorphisms and hypertension risk, but no meta-analysis has been conducted.

Materials and methods:

Five studies were included in this meta-analysis in total. The pooled odds ratio and its corresponding 95% confidence interval were calculated by the random-effect model.

Results:

The overall pooled odds ratio of the distribution of rs3761581 G allelic frequency was 0.90 (95% confidence interval: 0.82-1.00). In female participants, the pooled odds ratio of the frequency of G allele was 1.01 (95% confidence interval: 0.89-1.14). For males, the pooled odds ratio of the frequency of G allele was 0.

SUBMITTER: Wang T 

PROVIDER: S-EPMC6376513 | biostudies-literature | 2019 Jan-Mar

REPOSITORIES: biostudies-literature