Comparative preclinical evaluation of a polymer-free sirolimus-eluting stent in porcine coronary arteries.

ABSTRACT:

Background:

Polymer-free drug-eluting stents (DES) without permanent-polymer coating may be associated with rapid vessel healing, providing a rationale to reduce dual-antiplatelet therapy (DAPT). The aim of the current study was to compare vessel healing of a polymer-free sirolimus-eluting stent (PF-SES), its bare metal stent (BMS) analogue to a permanent polymer-based sirolimus-eluting stent (SES) with proven effectiveness in porcine coronary arteries.

Material and methods:

An ultrathin-strut cobalt-chromium PF-SES, its BMS analogue and an SES with a permanent polymer were used to study vessel healing and their antistenotic potential. Stents were implanted in porcine coronary arteries for histopathologic analysis at 7, 28 and 180 days. In an additional in vitro study, the t

SUBMITTER: Sperling C 

PROVIDER: S-EPMC6376525 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature