Correlation Patterns Between DNA Methylation and Gene Expression in The Cancer Genome Atlas.

ABSTRACT:

Background

DNA methylation is a form of epigenetic modification that has been shown to play a significant role in gene regulation. In cancer, DNA methylation plays an important role by regulating the expression of oncogenes. The role of DNA methylation in the onset and progression of various cancer types is now being elucidated as more large-scale data become available. The Cancer Genome Atlas (TCGA) provides a wealth of information for the analysis of various molecular aspects of cancer genetics. Gene expression data and DNA methylation data from TCGA have been used for a variety of studies. A traditional understanding of the effects of DNA methylation on gene expression has linked methylation of CpG sites in the gene promoter region with the decrease in gene expression. Recent st

SUBMITTER: Spainhour JC 

PROVIDER: S-EPMC6376553 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature